Cheesy as it may be, I don't see the point of adapting Mysterio without incorporating his iconic look in some form, and as in the image you used I would imagine it would be adapted similarly to his design in Shattered Dimensions.
If they're still steering clear of Doc Ock and Osborn, then the only A-List classic villains still left to be adapted are Chameleon and Kraven, unless we start diving into the mobsters (Hammerhead).
I thought it might be Gwen.