"He's pure power and doesn't even know it. He's the best of us."-Matt Murdock
"I need a reason to take the mask off."-Peter Parker
"My heart half-breaks at how easy it is to lie to him. It breaks all the way when he believes me without question." Felicia Hardy
I would argue the JMS era had Aunt May as one of the most interesting and probably just best characters in general. She's great when she becomes an active participant in the rest of the stories and not just as a reactive on the sideline. I would also argue in the Worldwide era and currently in both Spencer and Taylor's books she's interesting because of that too, she's doing things.
The least interesting?, wouldn't go as far, i think that he was a bit passive during Hunted, but it was still a great tale and did a good service in order to fix the damage made by Kraven's resurrection, but so far i'm happy with his take.
"Wow. You made Spider-Man sad, congratulations. I stabbed The Hulk last week"
Wolverine, Venom Annual # 1 (2018)
Nobody does it better by Jeff Loveness
"I am Thou, Thou Art I"
Persona
"Wow. You made Spider-Man sad, congratulations. I stabbed The Hulk last week"
Wolverine, Venom Annual # 1 (2018)
Nobody does it better by Jeff Loveness
"I am Thou, Thou Art I"
Persona
aunt bae is always interesting
I don't blind date I make the direct market vibrate
Kindred is the main storyline which isn't supposed to be revealed yet so I imagine it may not seem like Peter is a big focus. As for the least interesting, well that's kind of silly to say, everything is building up to focus on Spider-Man I sure wouldn't read a comic about a weird centipede guy tormenting Mysterio while some civilians did stuff without some central character surrounding it.