Best Marvel Comics With A Female Lead

[Rochedalaix]

Magik: Storm and Illyana

I would love to see that 4 part mini series as a movie.

[UltimateTy]

Alias was awesome, that's Bendis at his best. I hope the Jessica Jones show is like that.

[mugiwara]

Alias by Bendis.
Daughters of Dragon by Palmiotti.
Heroes for Hire by Palmiotti.
Mekanix by Claremont.
Runaways by BWK.
Runaways by Whedon.
She Hulk by Slott.
She Hulk by Byrne.

[krazijoe]

Captain Marvels (monica) run as Avengers leader in the 80's.

[Wind Rider]

Storm and She-Hulk spring to mind as top runners.

[JediMindTrick]

X-men Legacy back when Mike Carey was writing it. It was basically Rogue and a rotating cast of supporting characters.

[King's_Gambit]

My all-time favourite is probably Alias.

As for what's coming out right now, I've been enjoying Black Widow and Captain Marvel well enough.

Despite the gorgeous artwork, Elektra bored the crap out of me, unfortunately. I haven't tried She-Hulk or Storm unfortunately; the characters never really appealed to me. That said, She-Hulk has (had?) some pretty nifty art.

I'd also like to give a nod to Kot/Walsh's current run on Secret Avengers, which is my favourite team book right now. It's not an all-female team, but given the very large roles played by Maria Hill, Black Widow, and Spider-Woman, it definitely feels spear-headed by strong female leads. It's also a freaking great book. (The rest of the cast, by the way, are Hawkguy, Nick Fury Jr., Coulson, and MODOK. So really, two of the three actual Avengers are female leads).

[Rochedalaix]

The best solo female book right now imo is Ms. Marvel by a long shot.

[Wellman]

Honestly, Marvel actually has a good selection. My personal picks in no particular order are...

Alias by Bendis
Daughters of the Dragon by Palmiotti and Gray
Journey into Mystery by Immonen
Spider-Girl by DeFalco
Ms. Marvel by Wilson
Captain Marvel by DeConnick
Sensational She-Hulk by Byrne
She-Hulk by Slott
She-Hulk by Peter David
Black Widow by Rucka
Black Widow by Liu
Black Widow by Edmundson
X-23 by Liu
X-Men: Legacy (the Rogue issues) by Carey

Edit: Curse my fading mind, I forgot another recent good one and a nice forgotten gem.

Red She-Hulk by Parker
Mystique by BKV

[klynn]

Lillyblue: You and I are so in sync! Name of the Rose and In Pursuit of Flight are my two favorite stories as well.

[Kencana]

On a less blatantly-biased note... Marjorie Liu's 'Name of the Rose' (Black Widow) has always been a real standout story arc in my mind. One of my all time favorites.

Aw, yeah! I like that arc too.

Pretty much I like Marvel female-lead comic book, but here's some of my favorite:
She-Hulk
Black Widow
X-23
Spider-Girl
Ms Marvel

I have yet to read Storm solo.