There would be a few minor issues with trying to fold the spiderverse into the MCU, but it's not entire unworkable.
He might think the alien invasion was a hoax, the way many today feel the moon landing was a hoax or the earth is flat. That can be mitigated with a single line of dialogue from someone rolling their eyes over Eddie's having a tin foil hat theory. It's not perfect... but they can probably get away with it.