There have been a lot of One More Day arguments but we don't typically consider what the comics would like if it hadn't happened.

When JMS made the decision to end his run on Amazing Spider-Man, what if editorial had decided not to go ahead with One More Day? We probably wouldn't have the unmasking, since there wouldn't be a reset on the way.

There might have been more satellite titles since the marriage does work okay in that context (It gives Peter a constant across the books to reference events in other monthlies) and without One More Day and Back in Black, the divide between sales of Amazing Spider-Man and sales of Sensational Spider-Man/ Friendly Neighborhood Spider-Man wouldn't be as significant.

There might not be a Miles Morales since that only came after the decision to kill off the Ultimate Peter Parker. Without Miles, there might not be a Spider-Verse or a Spider-Gwen.