It's a great run but it might not be for everyone. Byrne's She-Hulk is a comedy book first and foremost with an emphasis on fourth-wall-breaking. If you enjoy that kind of thing then I think you will like it. I am not overly well-read on Byrne's other work so I can't say if you will like it based on his other work.
Separating Byrne as a person from his work also helps in liking this run.