It's the "Original Position" Dilemma. Much of the debate comes from who the reader can identify most with. The problem is that Mutants are a fictional group and thus while people can identify with and relate to them, they'll never truly be a part of the group. Because of that, many readers will default to "humans"'s side. It's a problem that later "Infamous" games had and I get a similar feeling from Yu-Gi-Oh! VRAINS in regard to the Ignis.