I think it refers to the Dominions. He says "We will know you forever. And I think is very likely we would not tolerate something like you having power over something like us." Dominions can survive the reboot of the universe but I don't think they like it.
Another thought, Galactus and Phoenix, enemies of the Dominions, are the only abstacts that have shown interest in mutants (Franklin Richards and Jean Gray / Rachel Summers / Hope Summers).