Seeing Apocalypse sitting alone in contemplation combined with Moira's journal thoughts on him, and Apocalypse knowing about the futures Moira has experienced has me thinking he could start seeing much of the mutant "race" as unfit if they lose in all the futures Moira has experienced; also that his whole modus operandi of making sure the fit survive and continue to evolve the human race (I say human as mutants are just humans with an activated x-gene) could be a way to combat against celestial threats such as the Phalanx. He and Sinister also have a history of genetic and technological alteration of existing mutants, mutates, and non-mutant humans so they know that that last future that Moira experienced where the humans supplant mutants through genetic engineering means their use of genetic engineering is something worthwhile if not perhaps necessary. I don't know if Hickman had these thoughts in mind with the scenes of him in silent isolated contemplation, but they fit. I think he and Sinister, if written well, could have some very interesting storylines.