I haven't been reading the X-books so I take your word on that. But I do think it's potent to Marvel leading to that Marvel-wide something with Ewing at the helm of it. I mean, they've stated as such. And several of the books are becoming more and more interconnected, so I don't think the Orchis mention in Hulk, nor it's ties with Shadow Base, is casual. I'll explain:
The interconnected parts:
Cap is on the run, currently, after having been falsely framed for Thaddeus Ross' murder. Ross was the original person who was head of the Shadow Base, and was given a billion dollar budget to dissect the Hulk and make more Hulks, ostensibly by the government. It was stated in Immortal Hulk that the Avengers didn't want to turn the Hulk's body over to Ross, at all, but their hands were tied because of
political pressure.
In Cap's book he is fighting a group called the Power Elite who are composed of the Lukins (with Red Skull), the Chadwicks, a terrorist group of white nationalists called the Watchdogs, AIM, Wilson Fisk, as the mayor of New York, and a new Scourge of the Underworld, whoever he/she may be. Also, Selene is a part of this group.
In this week's Immortal Hulk it was mentioned that Ross, unlike Hulk and Rick Jones, is perma dead. Another interesting part here is that the Power Elite are controlling public perception of regular folks through the Marvel equivalent of Fox News. And Ewing also wrote in yesterday's Hulk about how podcasts are used to sway public perception towards who's an enemy of the people and who is not. So again, shady government. Humanity being apathetic. The rich, like the Lukins, the Chadwicks and Fisk controlling the public and running things behind the scenes.
In Avengers, Invaders, the War of the Realms event and now Hulk, too, Roxxon, an evil corporation whose CEO is Dario Agger, the Minotaur has been a major presence. Roxxon sided with the Dark Elves during WotR. They killed Atlanteans rather ruthlessly in Avengers. They stole Namor's bomb, which turns humans into Atlanteans, in Invaders. They been hinted to have their hands in politics as well, owning several politicians. Well, not so much hinted as blatantly stated in both Avengers and Invaders. I asked Zdarsky about the connection between Avengers and Invaders re:Roxxon, he said it was absolutely deliberate. And now, in Hulk, Roxxon has become a target of Bruce Banner/Hulk and Namor, who have teamed up specifically to take them down. A bunch of us think that the real reason Namor turned Xavier down (other than the fact that Xavier and Namor have a personal beef, which was addressed in Invaders) is because Namor has his own war to rage on certain groups within humanity, and he and Hulk (Defenders!) are committed to doing it their way.
Before Ross was killed, he and Steve had an altercation in Avengers (which undoubtedly made it easier to frame Steve for his murder). It was over the fact that the Avengers voted T'Challa as chair and stated that they do not belong to any one government, thus them moving to the arctic and living in the hollowed out shell of a Celestial. Ross expressed concern that the Avengers now had firmer ties to Wakanda than the US. Steve told him to @#$% off in not so many words. Because of this, and because Namor cut the oceans off from humanity (for which no one can blame him, really), the US and Russia built their own superhero teams, both of which are eager to go after (declare war on) both the Avengers and Atlantis. All of this was orchestrated by Mephisto, who has a giant chessboard with all of these individual players on it, including a little Star Brand piece, and a little Kree Supreme Intelligence piece.
You also have that Weapon Plus solo featuring a Wolverine and Cap team-up that happened a few months back with the promise of more being involved with that story.
Yesterday's Immortal Hulk did a lot to tie this all together. The seeds are there. And like I said, I don't think Ewing name dropping Orchis, particularly in its connection to a government funded program meant to recreate the Hulk, is a coincidence. The overall reaching theme is government corruption, an Earth on the brink of collapse because of environmental concerns, the rich controlling things to their profit and their benefit, evil corporations literally ruled by devils, and humanity, as they did in Secret Empire, either not caring, or even embracing things as they are, though they are largely being manipulated into doing so or just haven't cared enough to fight it. Hell, Dario Agger said it outright in yesterdays Hulk. Humanity doesn't see it because it's easier not to.
Anyway, I believe that yes, war is coming, but I don't think it will be Avengers vs. X-Men, I believe that it will either be an Earth-is-doomed-due-to-the-greed-of-man scenario, and the Avengers and X-Men put aside their differences to stave that off, or government/evil corporations/Mephisto/etc. do everything they can to take out both groups, and supes and X-Men have to fight for their survival against them.