If he only said "genetic anomaly", then it could be just a hint that she'd have Spider-powers.
And this talk of Cyke and Spidey reminds me I've only seen them interact twice, once in Secret Wars and another in some story that is basically the prologue of AvX, in both Cyke used his optic blast on Spidey, kinda weird that's what I just happened to see with 'em lol.
As for interactions between them, honestly I imagine that they would have no chemistry and try to interact anyways, but can't ever get far in whatever subject they try to start lol.
Just hope that if they do interact we don't have that generic shit of "I don't like Spider-Man because he makes too many jokes", 'cause Cyke is used to being around people like that, and he's ultimately a patient guy, he can not like Spidey for other reasons, just do it in a way that'd be in-character.
Also Jack, in the conversation up there, you missed the opportunity of having Cyke mention that he's now working with Sinister, and for Spidey to be shocked at the very idea of working with someone who made clones of him
.