TV Actor/Actress that successfully played more than one popular role

[babyblob]

How about Soleil Moon Frye with Punky Brewster and Sabrina The Teenage Witch.

[WestPhillyPunisher]

How about Soleil Moon Frye with Punky Brewster and Sabrina The Teenage Witch.

Speaking of which, there’s Melissa Joan Hart who starred as Sabrina, and before that, Clarissa Explains It All.

[Zero Hunter]

How about Ted Danson?

Cheers - 11 Seasons
Becker - 6 Seasons
The Good Place - 4 Seasons

[babyblob]

Cant believe no one has said her yet but how about
Holly Marie Combs - Picket Fences and Charmed

[Nate Grey]

Cant believe no one has said her yet but how about
Holly Marie Combs - Picket Fences and Charmed

Probably cause we're in the minority of people who even remember that show.

Speaking of Picket Fences...

Mandy Patinkin = Dr. Geiger on Chicago Hope, Jason Gideon on Criminal Minds
Thomas Gibson = Dr. Nyland on Chicago Hope, Greg from Dharma and Greg, Hotchner on Criminal Minds
Héctor Elizondo = Dr. Waters on Chicago Hope, Ed on Last Man Standing
Rocky Carroll = this is in reverse, he was Joey on all seasons of Roc, then Dr. Wilkes on Chicago Hope
Mark Harmon = Dr. McNeil on Chicago Hope, Jethro Gibs on NCIS

EDIT: I forgot Adam Arkin. Even though he was only on 10 eps of Northern Exposure, IMO he left a lasting impression and even won a VQT (Viewers for Quality Television) award for his character, also named Adam, in 1992. He later went on to play Dr. Shutt on Chicago Hope.

[Jim Kelly]

Speaking of Mark Harmon, ST. ELSEWHERE was a medical series that had a cast of young actors that would go on to many other roles, as well as established actors that had already appeared on previous shows.

In addition to Harmon, there was--

Denzel Washington
Ed Begley Jr.
Howie Mandel
David Morse
William Daniels
Ed Flanders
Norman Lloyd
Stephen Furst
Bonnie Bartlett
Bruce Greenwood
David Birney
Alfre Woodard
Ronny Cox
Herb Edelman

[Rise Above]

Bill Cosby:

I Spy- Alexander Scott (82 episodes)

The Bill Cosby Show- Chet Kincaid (52 episodes)

The Cosby Show- Heathcliff Huxtable (197 episodes)

Cosby- Hilton Lucas (95 episodes)


Bob Newhart:

The Bob Newhart Show- Dr. Bob Hartley(142 episodes)

Newhart- Dick Loudon (184 episodes)

Bob- Bob McKay (33 episodes)

George & Leo- George Stoody (22 episodes)

[Malvolio]

How about Ted Danson?

Cheers - 11 Seasons
Becker - 6 Seasons
The Good Place - 4 Seasons

And don't forget his time on CSI.

[Midvillian1322]

I havent combed through the thread so its probaly already been said but Donald Glover Community and ATL

[babyblob]

How about Gerald McRaney

Simon and Simon
Major Dad
Promised Land
13 Episodes of Deadwood

[WestPhillyPunisher]

How about Gerald McRaney

Simon and Simon
Major Dad
Promised Land
13 Episodes of Deadwood

He also had a role on House of Cards.

[babyblob]

Here's another one
Tom Bosley.
Here of course was in Happy Days.
Did the voice for the american dub of The World of David the Gnome.
And was in Father Dowling Mysteries.

[Jackalope89]

Will Friedle in Boy Meets World (Eric Matthews), Kim Possible (Ron Stoppable), Batman Beyond (Terry McGinnis), and a ton of other roles.

[Sandy Hausler]

William Shatner: Star Trek and TJ Hooker

If we're talking William Shatner, don't forget his brilliant turn as Denny Crane on Boston Legal!

[ChrisIII]

Speaking of which, there’s Melissa Joan Hart who starred as Sabrina, and before that, Clarissa Explains It All.

Could current Sabrina Kiernan Shipkra herself count? She pretty much was one of the main characters of Mad Men, especially around halfway through.