TV Actor/Actress that successfully played more than one popular role

[CliffHanger2]

Avery Brooks-A Man called Hawk, Captain Sisko

[CRaymond]

America Ferrara - Ugly Betty, Superstore
Judith Light - Who’s The Boss, Ugly Betty, Transparent
Alyssa Milano - Who’s The Boss, Charmed
Christina Applegate - Married With Children, Samantha Who, Dead To Me
Allison Janney- West Wing, Mom
Alison Brie - Community, Mad Men, GLOW
Heather Locklear - Dynasty, TJ Hooker, Melrose Place
Margot Martindale - Sneaky Pete, The Americans
Keri Russell - Felicity, The Americans
Teri Hatcher - Lois & Clark, Desperate Housewives
Courtney Cox - Friends, Cougar Town
Christa Miller - The Drew Carey Show, Cougar Town
Sarah Chalke - Roseanne, Scrubs

[Powerboy]

Lee Majors: Heath Barkley in "The Big Valley", Lt. Col Steve Austin in "the Six Million Dollar Man" and Colt Seavers in "The Fall Guy".

Dennis Weaver: Chester on "Gunsmoke", Tom Wedloe on "Gentle Ben" and Marshall Sam McCloud on "McCloud".

James Garner: Brett Maverick and Jim Rockford.

Lucille Ball: Lucy Ricardo, Lucy Carmichael and Lucy Carter.

Robert Conrad: Tom Lopaka (Hawaiian Eye), Jim West (The Wild Wild West), Paul Ryan (The D.A.), Jake Webster (Assignment Vienna), Pappi Boyington (Baa Baa Black Sheep/ Black Sheep Squadron), Duke Ramsey (The Duke), Thomas Sloane (A Man Called Sloane), Jesse Hawkes (in both "High Mountain Rangers" and the spinoff, "Jesse Hawkes") and Griffin Campbell ("High Sierra Search and Rescue").

[Osiris-Rex]

Katey Sagal - Married with Children, Furturama

Michael Chiklis - The Commish, The Shield, Gotham

Don’t forget Sons of Anarchy.

As for her Married With Children co-star Ed O’Neill, he’s currently starring in Modern Family.

Katey Sagal also played the mom to Kaley Cuoco's character in 8 Simple Rules. In a nice bit of meta-casting, Katey Sagal also played Penny's mom on The Big Bang Theory.

[babyblob]

Christa Miller - The Drew Carey Show, Cougar Town

She was also in Scrubs.

[CRaymond]

She was also in Scrubs.

I thought the rules required them to be a star and not a recurring character?

[Innocent Bystander]

Allison Janney- West Wing, Mom

How did it take 4 pages to get Allison Janney?

But then we also have Bradley Whitford (West Wing, Studio 60 on the Sunset Strip, Transparent, A Handmaid's Tale), John Spencer (LA Law, West Wing), Rob Lowe (West Wing, Parks & Recreation), Dulé Hill (West Wing, Psych, Suits), Elisabeth Moss (West Wing, Mad Men, A Handmaid's Tale), Richard Schiff (West Wing, Ballers, The Good Doctor), Emily Procter (West Wing, CSI Miami)...

[babyblob]

How about Troy McClure? You may remember him from such shows as
Troy and Company's Summertime Smile Factory, Buck Henderson, Union Buster, and Son of Sanford and Son

[Arfguy]

Honestly, I've never watched the shows, but...

...would Thomas Jane count as someone who was in Hung and the Expanse?

[Osiris-Rex]

Kate Mulgrew - Star Trek: Voyager as Captain Janeway and Orange is the New Black as "Red".

[Jim Kelly]

Oscar and Emmy winner Sally Goddamn Field in GIDGET, THE FLYING NUN, ER, BROTHERS & SISTERS.

Burt Reynolds in GUNSMOKE, HAWK, DAN AUGUST, OUT OF THIS WORLD, EVENING SHADE.

David Soul in HERE COME THE BRIDES, STARSKY AND HUTCH.

Bobby Sherman in SHINDIG, HERE COME THE BRIDES, GETTING TOGETHER.

Gene Barry in BAT MASTERSON, BURKE'S LAW, THE NAME OF THE GAME.

Jack Klugman in THE ODD COUPLE, QUINCY M.E.

Jack Lord in STONEY BURKE, HAWAII FIVE-O.

Gerald McRaney in SIMON & SIMON, MAJOR DAD.

Simon Baker in THE GUARDIAN, THE MENTALIST.

Judd Hirsch in TAXI, DEAR JOHN, NUMB3RS.

Marilu Henner in TAXI, EVENING SHADE.

[CRaymond]

How did it take 4 pages to get Allison Janney?

Cause this list has skewed male... which is why I listed only actresses.

So...

Cybill Shepherd - Moonlighting & Cybill
Tichina Arnold - Martin & Everybody Hates Chris
Tisha Campbell-Martin - Martin & My Wife and Kids
Tracee Ellis Ross - Girlfriends & Blackish
Kim Fields - Living Single & Facts of Life
Jackee Harry - 227 & Sister Sister

[caj]

Jackee Harry - 227 & Sister Sister

Marla Gibbs - The Jeffersons and 227

[beatboks]

Robert Conrad: Tom Lopaka (Hawaiian Eye), Jim West (The Wild Wild West), Paul Ryan (The D.A.), Jake Webster (Assignment Vienna), Pappi Boyington (Baa Baa Black Sheep/ Black Sheep Squadron), Duke Ramsey (The Duke), Thomas Sloane (A Man Called Sloane), Jesse Hawkes (in both "High Mountain Rangers" and the spinoff, "Jesse Hawkes") and Griffin Campbell ("High Sierra Search and Rescue").

I loved the Black Sheep, wild west, and a man valled Sloane (who played the side kick guy with the robot hand and detachable tools?)

[Jim Kelly]

Richard Dean Anderson went from GENERAL HOSPITAL to MACGYVER to STARGATE SG-1 (and other Stargate series).