TV Actor/Actress that successfully played more than one popular role

[AnakinFlair]

Can't believe I haven't seen this one yet:

Alysson Hannigan for Buffy and How I Met Your Mother.

Also:

Eliza Dushku- Buffy and Dollhouse, and Tru Calling

Melissa Benoist - Glee + Supergirl

Jesse L. Martin - Law & Order + The Flash

Continuing with the Arrowverse:

Grant Gustin - Glee + The Flash

Katie Cassidy - Gossip Girl + Supernatural + Arrow

Willa Holland - The O.C. + Arrow

Caity Lotz was on Mad Men, I believe, though I don't know how big her roll was. So was Daniel Panabaker, I think. They went on to be on Arrow and Legends for Lotz, and The Flash for Panabaker.

John Barrowman - Dr. Who + Torchwood + Arrow/Legends

Neal McDonough has been in a ton of stuff. Along with his roll on Arrow and Legends, he was also in Suits and Yellowstone most recently.

Katrina Law - Spartacus + Arrow

Manu Bennett - Spartacus + Arrow

Colton Haynes - Teen Wolf + Arrow

Tyler Hoechlin - Teen Wolf + Supergirl

Wentworth Miller and Dominic Purcell- Prison Break and The Flash/Legends

Callista Flockheart - Ally McBeal + Supergirl

Victor Garber has been several different characters at the same time. We know him as Professor Stein from THE FLASH and LEGENDS OF TOMORROW, but he's also been working on other series like POWER and TALES OF THE CITY and CHARLIE'S ANGELS. Before that he was on ALIAS and THE FAMILY STONE. To name but a few.

He'll always be Thomas Andrews in Titanic to me

[j9ac9k]

Can't believe I haven't seen this one yet:

Alysson Hannigan for Buffy and How I Met Your Mother.

She's mentioned in the second post of this thread.

[Denirac]

Its crazy this thread's gone so far without mentioning Tom Cavanagh:

Doctor Harrison Wells, Eobard Thawne, Harry Wells, HR Wells, Sherloque Wells, Nash Wells, Grodd (controlling Wells), Wells 2.0, Herr Wells, Hells Wells, Wells 2.0, H. Lothario Wells, Sonny Wells, Wolfgang Wells, Wells the Grey, Pariah, Mime Wells, Steampunk Wells.
And some other stuff like Scrubs and Yogi Bear. You cannot say Tom's been Typecast.

[Sacred Knight]

Haven't seen this one yet, Johnny Galecki first as David on Roseanne then as Leonard Hofstadter on Big Bang Theory.

[Osiris-Rex]

Haven't seen this one yet, Johnny Galecki first as David on Roseanne then as Leonard Hofstadter on Big Bang Theory.

Also Sara Gilbert played Darlene Connor on Roseanne and Dr. Leslie Winkle on The Big Bang Theory (She was a series regular for a season or two so that counts)

[caj]

I've seen Betty White and Rue McClanahan mentioned, but let's not forget:

Bea Arthur - Maude and The Golden Girls

Also:

Joey Lawrence - Blossom and Melissa & Joey

Melissa Peterman - Reba and Baby Daddy

[Jim Kelly]

Jean Smart is an interesting case. Because when she was on DESIGNING WOMEN, I thought hers was the most boring character on that show and I really didn't think she was much of an actress. I guess I assumed she was playing herself. But since then I kept seeing her show up in one good role after another and displaying a lot of range.

[CliffHanger2]

Lee Majors-Six Million dollar Man and Fall Guy.

Avery Brooks-A man called Hawk. Deep Space Nine-Captain Sisko

[Zero Hunter]

Its crazy this thread's gone so far without mentioning Tom Cavanagh:

Doctor Harrison Wells, Eobard Thawne, Harry Wells, HR Wells, Sherloque Wells, Nash Wells, Grodd (controlling Wells), Wells 2.0, Herr Wells, Hells Wells, Wells 2.0, H. Lothario Wells, Sonny Wells, Wolfgang Wells, Wells the Grey, Pariah, Mime Wells, Steampunk Wells.
And some other stuff like Scrubs and Yogi Bear. You cannot say Tom's been Typecast.

Lets not forget he also had a great show on NBC called Ed that he was the main star of that lasted 4 seasons.

[Malvolio]

Lee Majors-Six Million dollar Man and Fall Guy.

Avery Brooks-A man called Hawk. Deep Space Nine-Captain Sisko

Lee Majors was also on Big Valley before Six Million Dollar Man.

[Cyke]

Lets not forget he also had a great show on NBC called Ed that he was the main star of that lasted 4 seasons.

Funnily enough, his character's full name was Edward Jeremy Stevens-Wells.

[Zero Hunter]

Has anyone said Andre Braugher? He did many years on Homicide: Life on the Streets and is now killling it as Raymond Holt on Brooklyn 99.