Start of the human genocide that mutantdom has been itching to carry out for so long. After homo sapiens has been extincted, mutantdom becomes radicalized enough to launch a universal campaign of xenocide to leave all existence to be the domain of mutants, Homo superior no more, but Deos superior instead.
Then Marvel does a Crisis reboot because the Disney overlords will never condone a story ending in a victorious genocide to stick.