While we've been focusing heavily on what to keep and what to ditch (and I agree you should ditch as little as possible), there's also the question of what comes next. This is where you can start restoring things to an earlier state that you prefer over where things left off, and/or building on aspects that got neglected over the years to do something new and interesting — as long as the result is still recognizably New 52.
That said: we have Futures End, which charts or the near-term future of the New 52. If we keep that in continuity, then we have a map of sorts on how Earth 52 develops after it diverges from Earth 0. I'm thinking in particular of the “five years from now” part; the further future is a potential future that Futures End prevents.