This hasn't not affected Deadpool and Spider-Man team-up series. Yet, they really don't have anything to do with each other at all. Not so different between Jessica Drew and Peter Parker, if we exclude their Spider-Costumes respectively. Jessica appearing as a reoccurring guest in the pages of Spider-Man will introduce her to the readers who has not picked up her titled book. Secondly, Jessica Drew and Peter are close friends. If there's anyone who understands her(besides Carol Danvers), it's Peter Parker. We need to see their friendship better established in the same manner as her friendship with Carol Danvers, whose also friends with Parker. Relationships are about shared interest, which needs to be explored. Not saying that it should be romantic.
What would be cool to see is a Spider-Man & Spider-Woman team-up mini series that combines their related adventures together. Remove the spider-costumes and you get two people with different backgrounds who share a common bond that has nothing to do with spiders....