No question there. Hell's bells,
Buffy:The Vampire Slayer dealt with all sort of creatures from demons, witches, mantis women, and lunch ladies.
And the MU has no shortage of monsters, and just plain horrifying things. One group of villains that Blade dealt with during his Nightstalker run was
D.O.A.(Department of Occult Armaments), originally a division of HYDRA. Specializing in acquiring, and developing an occult based arsenal for the organization. Thought to have been put in the dust heap when their vampire super-soldier, Bloodstorm, went all Columbine on his creator, and killing the head of D.O.A., Lt. Belial. But the group reappeared later in the post
FEAR ITSELF maxi-series, subtitled
The Fearless. Under the new management of the Red Skull's daughter Sin, and Crossbones. I could see the group giving Blade some trouble in his own mag. Or looking at the following fan trailer, the HYDRA splinter faction could be the villains for the upcoming MCU
BLADE entry.