So, assuming the MCU Spider-Man films are building up to Peter having a recurring arch nemesis like what Loki is/was to Thor, the question that needs to be asked is who should it be? There are two villains that would classically be the right fit: Green Goblin and Doctor Octopus.
There's cases to be made for both of them. Norman Osborn is probably the most recognizable of Spider-Man's villains and the one who's most classically thought of as Spidey's biggest villain cuz of the original arc surrounding his identity and is the one who has had the biggest impact on the wider Marvel Universe. He was the head of H.A.M.M.E.R. and created the Dark Avengers. So, they could position him as the next big villain of the MCU. In fact, there was quite a lot of talk a while ago that they were going to do just that.
He's also arguably the one who has caused Peter the most personal pain. He kidnapped Aunt May and faked her death, he abducted Peter and MJ's newborn baby (something not followed up on to this day), killed Gwen Stacy, orchestrated the Clone Saga, etc. So, the list is long.
Then there's Doctor Octopus. There has been some consensus that Octavius has taken over from Osborn as Peter's nemesis due to a string of high profile stories, most notably the Superior Spider-Man arc. He was also the one who orchestrated the Sinister Six coming together. He has a list of notable moments fighting Peter as long as Norman's.
So, what do you guys think? Make the case: Green Goblin or Ock? Or should it be Kraven instead?