That would actually be rather interesting to see.
I've always wondered if this already did happen when the two of them were living together on the Avengers Asteroid Base for months. Miguel didn't come out of the closet until after that period...so I figure something probably happened out there, either with Wendell or with Eros...
God, yes!
Depending on which Iron Man you're referring to, this one might violate the O.P.'s rule against pairs that have already dated, slept together, etc. Tigra and Iron Man (Tony Stark) did go out on a date back in the WCA days (when Iron Man rejoined the team and was still pretending that he wasn't Tony Stark). She had also made advances on him earlier in the series--but at that point she was making advances on every single guy due to the imbalance with her powers...
LOL. Love it.