Excluding origin stories, what are the most notable permanent deaths?

[Hybrid]

What are the most notable permanent deaths, outside of a characters' origin story? Thus, no examples like Uncle Ben.

Some that come to mind:

Abomination
Baron Heinrich Zemo
Copycat
Genis-Vell
George Stacy
Goliath
Gwen Stacy
Hornet
Jean DeWolff
Justin Hammer
Karen Page
Mar-Vell
Robert Kelly
Thunderbird

Of course, comics being what they are, who knows if this ends up getting contradicted later. Anyways, what other notable examples are there?

[Snoop Dogg]

Talbot and Stane.

[K7P5V]

The original Swordsman

[Hybrid]

8-Ball
Electro
Happy Hogan
Microbe
Ned Leeds
Vision (Jonas)

[DigiCom]

Skurge the Executioner.

"…and that answer is enough."

[H-E-D]

Does Mar-Vell count or have there been too many fake Outs?

Skurge the Executioner.

"…and that answer is enough."

Pretty sure Skurge has come back in recent years.

[Ravin' Ray]

Franklin Storm.

I have a feeling that the body count for family, relatives and supporting characters of superheroes (and even supervillains) is going to be high. They're either fridged, bait, in the line of fire, or sacrifice themselves.