Up here North of the border, I wasn't aware that she didn't run for re-election. In that case, you are probably correct, she could be a valuable asset for Republicans if she can win a swing riding in Hawaii.
Traditionally, the Democrats have always had a religous fraction that is not onboard with LBGT rights, (Catholic ect) but if you want to go anywhere in the party...you can't hold her views.
Yes that whole episode surrounding Bashar - al - Assad, and chemical weapons was bizarre. Off the top of my head, I can only think that she's supportive of Shia Muslims and Iran and Hezzbolah. This is usually a position taken by the far left though, particularly members of the Labour Party in the UK, so it seems like she has a lot off weird hodge podge of stuff going on in her head.