Even in 616 an end is possible. How? Peter dies or retires with MJ, and Miles takes over. Why? Maybe Miles becomes more popular then Peter. As Revolutionary Jack pointed out it is the Spider-Man character ( more then Peter) that is profitable to Disney/Marvel. Maybe in 10 years, Miles outsells Amazing and the kids of tomorrow prefer Miles cartoons, toys and games to that of Peter. Is it probable? No but not out of the realm of possibility.