The current story line in Spider-Woman about Gerry being kidnapped, aged up and brainwashed into an assassin sparks a dark thought about a world with super humans.
They are a commodity. Governments, terrorist groups, corporate interest, etc...are going to want them as a resource.
Russia had the Red Room and the Red Guardian programs and the Soviet Super Soldiers that evolved into the People's Protectorate and then the Winter Guard
,
China had China Force, the People's Defense Force, The Dynasty and even their own S.H.I.E.L.D. type organization S.P.E.A.R.
North Korea using Bartol Utler's process for grafting the x-gene onto people to create their own super humans.
The USA and their Freedom Force and Thunderbolts programs using criminals and the Squadron Supreme of America before that imploded.
Serval Industries funded X-Factor for a time.
Even Iron Man was a corporately sponsored hero...as far as the public knew.
Then there are the terrorist, criminals, etc...who recruit or create their own super human assets.
I think there would be many interesting stories to be told dealing with these concepts. Breaking a super human trafficking ring (yes I know Young Justice did it), or super human assets of opposing governments carrying out a shadow war in modern time and even in the past.