The Infinity Stones have been around in the 616-universe long enough to rack up some feats. We all understand that the combined power of all six stones is a huge threat in the 616 universe, with a synergy far beyond the abilities of the six separate stones. But which stones have the most effective synergy if a character could only wield two of them? My guess would be Reality + Power, but maybe the reality alteration comes up short without certain other stones, like say Mind or Time.