Is it his friendship with Johnny Storm the Human Torch? Or Matt Murdock The Daredevil? He has teamed wioth both more times then I can count. I like the The Human Torch and Spiderman had a rivalry going and were not very friendly at first but that has grown into respect and friendship.
So which one do you think means more? Which one has been written better over the years? Is there another hero that Spiderman is friends with that you like.