On one side, the girlfriend of Peter Parker, the one that had a tragic death. No powers, and a supporting character in Peter's book.
On the other, the one and only Spider-Woman of Earth-65. A lead character on her own right, and never a helpless victim.
Which one do you like best?
By the way, yes, I know that there are a few other notable ones, such as Ultimate Gwen and Emma Stone's Gwen. But to keep things focused, let's stick to the main ones.