I feel like the classical theme that Priscilla represented, women preying and tearing down other women to prop themselves up to contrast the themes of sisterhood of the Amazons, is still present here and could be expanded upon.
But really, I don't know if an ideological opposition is a requirement for arch nemesis status. I don't know that Lex, the Joker or the Green Goblin have consistent ideological oppositions to their respective arch enemies, most of it is the personal history that seals the deal. or they function as black mirrors like Barbara does for Diana. Arguably the Joker was a much better character before they started applying the "agent of chaos" ideology onto him.
I think there is enough context clues to let us know her own recklessness/ambitions lead her down her path and Godwatch just sped it along, but some of it may be down to Rucka leaving the book when he had more he wanted to do.
I think the atmosphere of Diana finding the transformed Barbara for the first time in the Godwatch arc is perfect, but I wouldn't be opposed to an Rucka/Scott Cheetah: Year One miniseries that re-tells that scene from her perspective