Do you mean replace him as Bat-Family leader, or his role in the Justice League? Because I could see Babs taking over as family leader, but I could see Kate in the Justice League.
I don't think Kate has the people skills to deal with a bunch of teenagers and 20-somethings, her leadership is more combat strategy. Babs on the other hand is better with empathy.
*****
Which reminds me, I keep forgetting Kate is a 20-something now, I'm so used to her original solo where she was in her 30s before the de-ageing of Rebirth. Babs used to be in her 30s at some point too, they all keep getting younger.
Bruce is still in his thirties, right? How old is Selina?