Glad this wasn't about MJ, those of us who read Reign know what her kryptonite ended up being.
Every day is a gift, not a given right.
"He's pure power and doesn't even know it. He's the best of us."-Matt Murdock
"I need a reason to take the mask off."-Peter Parker
"My heart half-breaks at how easy it is to lie to him. It breaks all the way when he believes me without question." Felicia Hardy
Love
Love of Aunt May
Love of Mary Jane
Love for others(innocents)
"Freedom is the right of all sentient beings" - Optimus Prime
Does drinking alcohol count? Spider-man seems to have bad term when it comes to drinking.
Funny, this thread's title reminds me the time Spider-Man actually became Kryptonite. Luthor and Octopus plotted against the heroes and kidnapped their wives (Lois Lane and Mary Jane), and Spider-Man thought Superman kidnapped MJ. Although Spider-Man is strong, is not at all as strong as Superman, so Luthor gave the webslinger certain advantage over Superman. He irradiated Spider-Man with Red Sun's energy, which combined with his own irradiated blood, turned him into a Red Sun's battery that was capable of hurting Superman. However, the effects didn't last long; and in the end, poor Spidey almost broke his hands after punching Superman several times.
"Wow. You made Spider-Man sad, congratulations. I stabbed The Hulk last week"
Wolverine, Venom Annual # 1 (2018)
Nobody does it better by Jeff Loveness
"I am Thou, Thou Art I"
Persona
I remember the one (?) time Spidey was drunk, it was an issue of Web of Spider-Man where he just moved into a new place with Mary Jane and they had a big party with lots of guests over and Peter drank the punch but it was spiked so he goes out and fights the Hobgoblin totally sloshed haha, I think he was really off his game naturally and the Hobgoblin almost beat him.