I honestly don't like ANY of the changes made in the comics to "synergize" with the MCU or any of the Sony/ Fox films. My least favorite is of course, retconning the Scarlet Witch and Quicksilver's status as mutants. (Like it or not, they debuted in X-Men as original members of the Brotherhood of Evil MUTANTS, and no amount of stupid explanations can remove the existence of those classic Lee and Kirby comics.)
Every story I have read that is intended to change the comic character to more closely resemble the films has varied to pointless and mediocre to outright offensively stupid trash. I did not enjoy that story where Spider-Man mutated into a giant spider and gave birth to himself with organic shooters and I didn't like that stupid Battlescars mini that introduced comic 616 versions of Nick Fury Jr. and Coulson either. The writing for both was just ....bad. Even when I prefer the film version of a character to the comic version such as Negasonic Teenage Warhead, the comic writing is always so amazingly and completely inept at capturing what made the screen version of the character so appealing.
I absolutely loathe SHIELD and I can't stand that the Avengers are basically now just a superhero gofer branch of it, and I could go the rest of my life with never seeing that organization "grace" the pages of my beloved X-books and Spider-Man. But even then, I still feel bad for classic Nick Fury fans. Editorial promised with the arrival of Nick Jr. that classic Fury would still be a reoccurring hero in Marvel comics, only for his last major role to toss him under the bus and leave him chained up on the moon. Renamed "The Unseen" and more or less removed from the Marvel Universe as a whole. (How very "clever.")
With that said, I wouldn't be opposed to them changing Aunt May to look more like Marisa Tomei and less like the host of "Tales From the Crypt."