I think like everyone already said. The best DC villains outside Metropolis and Gotham are from Green Lantern and The Flash, which is: Sinestro and Thawne. The second best might be Black Adam. But that actually brought me a question, who are the best villains outside the villains of the Seven? I think it will be Shade, Onomatopedia, Trigon, and Darkseid. What is Darkseid considered as Superman's villain despite being the nemesis of Orion?