The big thing for relevancy for a particular character is if there's anyone actually championing them behind the scenes. You can kind of see this shift at Secret Wars where Kaine lost just about all relevancy in favor in Miguel being brought to the present, Miles transferring universers, and them trying to capture lighting in a bottle with Spider-Ock. Especially with Spider-Ock, Kaine's entire niche of being the "edgier" Spider-Man got completely supplanted.
The artist formerly known as OrpheusTelos.
But that kind of loops back to my idea that there's no one really advocating for Kaine or Ben Reilly for that matter. For better or worse, Nick Spencer seem to have gone out of his way to avoid treading old ground of Dan Slott's run after and I think the Clones is another area they're not in a real rush to revisit.
The artist formerly known as OrpheusTelos.
As far as a regular job goes, I want to see him working as an Civil Engineer or Architect. The revelation is that Kaine has his college degree at the Masters Level in Engineering. This would set him a part from Peter Parker. As far as love interest goes, I feel that Heather Douglas(Moondragon) or Dr. Moira MacTaggert(X-Men) would fit Kaines personality quite well...
Well I like him. Or at least liked him with the long hair, cloak and gnarly tights. He's like your partly insane uncle who always ruins Thanksgiving dinner. Instead they've put him in a Spider-Man suit and then tried to give him normalcy. Making him even more similar to the original Peter Parker is dumb.
But the fact remains he is just a knock off Spider-Man no matter how you slice it. Hence - not that popular.
Every day is a gift, not a given right.
I like Kaine. He has Spider-Man powers, but with a Wolverine attitude. He still has the responsibility, but will go to some brutal ends to ensure it. That inevitably causes him to be a lot more battered and battle damaged than Peter. I've always said that's one of the reasons why I like Kaine, you can beat and bloody him in ways that Pete couldn't.
For me, what holds Kaine back is the personality. I get that he's damaged and brutal, but I don't see that many character moments where he displays this. More often then not he seems pretty awkward in situations with other characters. With Pete, I know that he'll try and be funny and cool whenever he gets nervous. But what would Kaine do?
So a more defined character would help Kaine out.
"I am a man of peace."
"A man of peace...who fights like ten tigers."
From what I recall of Chris Yost's take on Kaine, whereas Peter tries to get along with the people he runs into and works with, with his jokes being a method of getting them to feel at ease with him, Kaine instead tries to drive them away from him by acting like a gruff, foul-mouthed jerk . . . not that that works very well. It's those damned Parker genes, I tell you! A popular meme that might sum it up well enough, though: "Kaine wants to be hardcore, but Houston [or Aracely] won't let him." And despite himself and his efforts to seem aloof, gruff, and uncaring, it's extremely obvious after a point that he does care and genuinely wants to be a better person, in honor of his clone brother Ben (before Clone Conspiracy mucked that up) and Peter.
The spider is always on the hunt.
I've long thought Kaine would be better served by having his original powerset returned: his hyper-spider powers were always fascinating to me and really sets him apart from other Spider-People, even more than The Other powers do.
-Pav, who hopes we see him again soon...
You were Spider-Man then. You and Peter had agreed on it. But he came back right when you started feeling comfortable.
You know what it means when he comes back.
"You're not the better one, Peter. You're just older."
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Beyond ridiculous. Kaine was an assassin prior to his appearance in the 90's clone saga, and pretty much a drifter at that, who spent his time pursuing Ben Reilly to make his life a living hell. Somehow you want to say in the 2-3 years he existed at that point he had time to get a graduate degree in engineering? Even if he had Peter's complete memories (which he doesn't), the timeline makes it impossible.
As for your choices in love interests go, I won't even dignify that with a response.