I think the marriage is one of those things that gets people passionately debating about it on either side, but its presence or lack thereof doesn't really impact sales much either way if the overall direction is well received. If there is no marriage in his run if he comes on board, some people will make a fuss online about it but if the series otherwise well received and sells well it won't matter too much. Plus, do we know how Waid feels about Lois in general? She could still be included, just not as a wife.
Lois is an essential part of the mythos, she's his main love interest and the unspoken endgame for when his story hypothetically ends...but I don't view the marriage as that essential or especially interesting despite how popular it is. I've actually always been more invested in the Spider Marriage. True MJ wasn't his first and only love, but Peter was designed from the ground up to be a character who grows and goes through arcs of a life story, from teen to adult, so marriage is a more natural part of his set up. And there was a lot of shared development between him and Mary Jane that made her the natural choice, which is why OMD is so bad. Clark meanwhile is a more archetypal/static character who doesn't have one consistent version. The versions of Clark and Lois who got married in post-Crisis weren't even the originals. Plus they just don't have compelling stuff like the death of Gwen or Harry becoming the Green Goblin to bring, their friendship circle falling apart, to bring them together as a bedrock for their marriage the way Pete and MJ did. It's never been as interesting as a marriage, IMO.