Non-comics:
1) Lois Lane - it's not as close as you would think, either, due to her three decades of cartoons, radio, television, Broadway, and movie serials before Diana ever made it out of the comics for the first time.
2) Wonder Woman - comfortably #2 and may make it to the top in the near future based on her movie roles.
3) Supergirl - the next two on my list actually have more appearances beyond comics than Kara, but starring in her own show and movie has its benefits.
4) Martha Kent
5) Lana Lang
6) Batgirl (Barbara Gordon)
7) Catwoman
8) Harley Quinn
9) Starfire
10) Raven
Honarable mention: Chloe Sullivan