This is Superman from The Dark Knight Returns animated film.
The girls mistake Superman for a Mojo Jojo genetic experiment and have to take him down; likewise, Superman sees the Girls as a Lex Luthor genetic experiment.
Round I) The original Powerpuff Girls (1998-2005 series) vs. this version of Superman.
Round II) The reboot Powerpuff Girls (2016-????) take on TDKR Superman.
Round III) Bliss (the original Powerpuff Girl from the reboot) vs. TDKR Superman.
Round IV) The Powerpuff Girls Z take on TDKR Superman.