Agreed. How many stories of "evil man" hatches hate plan against mutant have we seen? Early on, these were plentiful, as the metaphor of mutants for LGTBQ or other minorities was closely trackable.
In the past two decades? No, not really anything closely related to real life. Schism has Cyclops vs X-men, which doesn't track with anything really. Bendis' run had time travel shenanigans again, and those stories don't really track with real life. All the other general outlines of X-books didn't add anything new.
X-books haven't really stood for anything for awhile now, aside from the general idea of a persecuted minority group, but that has mostly taken a backseat to superheroics.