The BND stuff is a very mixed bag in all honesty. I remember when I was younger, I kind of fell off it after a while.
The stuff that directly succeeds OMD is absolute crap, with the worse coming from Slott of all People. A few seeds for later story arcs are planted, but it's pretty worthless. I'm going to be honest, I don't like Mr Negative. I enjoyed the game a lot and enjoyed the parts with him in it, but I really don't care for him.
I'd say read #600 and then skip to Big Time. Big Time is a much better era in my opinion.
OMIT is a contender for worst Spider-Man comic, the only other contender I can think of is OMD.