Fundamentally, Peter's biological parents don't matter, and his mother's family not at all. He was raised by Ben Parker and his wife May, Ben is brother to Richard, Peter's dad.
For the story to work, Ben and May, have to count and matter more for Peter than anything else.
So it's moot.
The Onion AV Club back in 2002 asked celebrities "If there's a God" and here's how Stan Lee saw it:
https://www.avclub.com/is-there-a-god-1798208251
That's an agnostic response if you want to put a label to it. Lee was someone who never gave a great deal of thought to religion, it seems to me. It's not there in any of his work. I think he was just secular.
Steve Ditko's family were Slovakian immigrants from the (former) Austro-Hungarian Empire and he was fully assimilated as a kid, but his parents might be first generation. So he might have grown up hearing and knowing a bit of the language of the old country. Ditko and Lee were kids who grew up in the Depression, and had a strong sense of family, i.e. uncles and so on. So I guess that's what gets reflected in Ben and May.
They modeled Peter's background and his circumstances on their teenage years before the war which explains why May and Ben are a bit like Depression-era characters. Like Aunt May probably looks like a struggling soul from the Depression years.
(One of my disappointments with Spider-Man Noir is that the people behind the scenes don't tap into the fact that Peter's co-creators came from the era, and grew up in the period the character is set in).