"My prediction? PAIN." --Clubber Lang, Rocky III
The PKJ run will have some cool world building but will neither be great nor terrible. Major reboot shortly thereafter. Bendis and his ideas will remain a key player in editorial (to the chagrin of many).
Red & Blue and Yang B/S will be the best of the litter by far. (seems like one of the easier predictions)
I do see them going more digital heavy and dropping more print titles as a continuation of the "bloodbath."