It totally might be, but then again, what is the point of Krypton being destroyed if it doesn't have any impact on Clark other than loneliness? Because that could still be achieved if Krypton was still alive.
I mean there are various stories about Aquaman where he was exiled as a baby and isn't alowed to come back right? And in Young Justice for example Miss Martian totally behaves like a human and tries to fit into human society despite Mars still being populated.