I think this was mentioned earlier in the thread, but Jac Schaeffer gave an interview where she said that in an early draft, the prophecy of Wanda destroying the world played a bigger role in the finale and was resolved when Wanda realized that destroying the Hex was the fulfilment of the prophecy (destroying the world she created).
They didn't go with this, and it's a good thing because they already had one huge bait-and-switch with Ralph. I just think that may indicate that the prophecy may not play much of a part in Strange 2. Other writers may wind up running with it in something else though.