I seriously doubt it.Saladin Ahmed doesn't strike me as the type who would have the guts to do such a thing.
I don't think anyone wants it to happen either because a)It's just pure disturbing
b)The fallout will need to be dealt with a certain amount of tact that I don't think Ahmed has or will risk
c)It's been a fairly kid-friendly book(aside from mindspinner)
That being said via solicits we know someone will die.
Also Spoilers
More importantly we just got 1610's offical return to the multiverse cemented.Looks like the maker will be the new big bad.I really hope we deal with Miles in the event and if his uncle is there do that along wioth the rest of his family.Maybe even keep him there if they think that would be better specially if 1610 is making a comeback in series after that.