Most Powerful Anti-Magic Weapon

[90'sCartoonMan]

Often times to even up the odds, a mortal or low-level power hero will get a weapon that can deflect or disrupt magic. Something along the lines of Samurai Jack's sword or Hawkgirl's mace on the Justice League cartoon. What's the ultimate weapon in all of fiction used by a non-god-like character that is the best against magical attacks?

[Wildling]

Often times to even up the odds, a mortal or low-level power hero will get a weapon that can deflect or disrupt magic. Something along the lines of Samurai Jack's sword or Hawkgirl's mace on the Justice League cartoon. What's the ultimate weapon in all of fiction used by a non-god-like character that is the best against magical attacks?

In Marvel Comics, human Zelma Stanton used the Sands of Nishanti in order to magically depower for 3 minutes Doctor Strange (who at the time was some dimension-transmutating God of Magic empowered by Yggdrasil) and Loki, so that they could only fight with their human and Frost Giant physiologies in the meantime.

[T51R]

Spellfire.

It turns the user into a magic convertor. Magic in one end, weaponized or not, spellfire out the other end, definitely weaponized. You can use Potterverse Unforgivable Curses on a Spellfire user all day long, and all you'll do is make them stronger and stronger.

Think of it this way, an untrained servant girl(Shandril Shessair) became worthy of Elminster's attention when her Spellfire abilities manifested. She then proceeded to massacre her way across three whole books before her mental instability caused her to take herself out. But even then, she isn't dead.

The moment you use Spellfire from this point on, you run the risk of Shandril's return.

The biggest problem with these guys is that they seem to be the Chosen Of Mystra, an actual Goddess. Why Shandril can return is because Mystra put her back together as what amounts to a bloody Spellfire Elemental. So she can't be killed after her first death, and I think you might need something like the Absolute Zero cannon to temporarily stop her, or the LHW's or Giga Slave to put her down for good.

[The Drunkard Kid]

It's somewhat inconsistent in its portrayal, but A Certain Magical Index's Touma Kamijou's Imagine Breaker has at its high end (well, from a couple of years back, anyway) let him deflect attacks from a God of Magic that was repeatedly destroying and recreating the universe in an attempt to break his will. And I think he also deflected the backwash from an attack from the actual (?) Hindu God Vishnu.

Not to mention that said anti-magic functionality (along with his ability to regenerate his right arm) is possibly just a side effect from its true nature as a seal for the invisible thing that resides in his right arm, which is allegedly even stronger than (the presumably Christian) God. Unless it is actually the physical embodiment of the subconscious wish of all magic users to have some sort of ultimate undo button in case they ever do something unforgivable, as theorized by that guy who was a candidate to become a Magic God himself.

[LordMikel]

The Darksword from the series by Weis and Hickman. All spells would simply be absorbed by the blade. I want to say if you stabbed a magical creature it would revert to non magic but it has been awhile since I reads the series.

[big_adventure]

The Ebony Blade carried by Dane Whitman in 616 was pretty potent - it could absorb, deflect and cut magic just like it did any energy.

Even stronger, I'd go with the Adjunct's Otataral sword in Malazan. Otataral is a metal found in the Earth on one island, and just the presence of it creates a radius that completely halts all warren-based magic (that's everything used by mortals, and most of what it used by gods in the series - only the stuff slung by a few characters in the series is resistant to Otataral).

[Shellhead]

Magik's Soulsword counters and breaks all spells and enchantments, and gets more powerful with every use.