I want to say that, in this reality, things are inhumanly cruel for Peter Parker. I mean, he lost Aunt May because of Hyperion's recklessness, he didn't start a formal relationship with Mary Jane; and it seems he never meet other regular people from his circle, like Harry, Gwen and others. The only good thing here is that Norman Osborn (the Green Goblin) became Nighthawk's problem as his "Joker".