At the end of the Mark Waid "History of the Marvel universe" run. Marvel has planting seeds some event that will happen in the future. So far, here are the summary with that happen so far:
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The Age of Khonshu: Jason's Avengers issue 34-38
The Interstellar Reign of the half-breeds: EMPYRE
The Rise of the Outlaw Generation: OUTLAWS
The King in Black: KING IN BLACK
The Defenders of Tomorrow: Defenders series
The Wedding of Emma Frost and Tony Stark: X-Men#26 and invincible Iron Man #10
Threadneedle and Warbird: Kurt's The Marvels run
The Fate of Mephisto: AVENGERS ASSEMBLE: OMEGA
The only event that hasn't happen yet but still possible in the future:
The tragic fate of Luke Cage and Jessica Jones's Second Child
What do you think about all these spectacular future?