It depends I guess on how No Way Home ends. Anyway, I always had a guess that NWH is the last Holland Spider-Man film or near the end.
People thought that Spider-Man would be around and so on, but the Shared Universe without Iron Man, Thor, Captain America isn't the one in which Holland originally appeared in. They have a bunch of new characters they want to get up there, they need to get Fantastic Four to work and bring in the X-Men, whatever it is that's happening with Black Panther Post-Boseman, and that's basically five years worth of work,
at minimum. Meanwhile they'll do what, an Avengers story with Holland Spidey, Paul Rudd Ant-Man, Doctor Strange, Hulk, War Machine, Captain America II? That's not something that would have a great deal of novelty for the audience. Without novelty, without expansion, without clickbait, the MCU dies.