It's obviously set up for MJ and Peter to find each other again spoilers:end of spoilers
(MJ: I figured out your identity once, I can do it again and the "Tell me when you find me again" speech).
It's also obviously set up for Ned spoilers:end of spoilers
to return and continue to use magic (Strange seemed very intrigued by Ned's ability to open portals) and for Ned to become Peter's Harry Osborn - and maybe Ned never does remember his friendship with Peter - mixed with Hobgoblin/Demogoblin (because of the magic).
I wouldn't be surprised if the MCU version of the Black Suit Saga might be in the works spoilers:end of spoilers
since we all know the MCU version of Venom has been seeded and I can see them introducing a Felicia who falls for Spider-Man but not Peter, and then for MJ to come back into the picture as someone who is friends with Peter but doesn't know he's Spider-Man - and Peter wants to keep it that way for fear of causing her harm again - but then she'll ultimately remember/put it together again as she told him she would.