Right, in comics and most media portrayals they were doing whatever they were doing and Spider-Man interfered (Much like Vulture in the MCU). MCU Mysterio got involved with Spider-Man because of EDITH, it wouldn't have mattered if Peter was Spider-Man or not, what mattered to him was Tony Stark giving EDITH to an unprepared child. I get the idea he would have went after Pepper if EDITH was given to her, as Spider-Man specifically didn't seem to matter to him. Beck was pretty content when he got those glasses, Peter/Spider-Man would have just been collateral damage. Even wiping out witnesses I get the impression it didn't matter who (i.e. if MJ didn't show Peter what she found, Peter wouldn't really have been in danger...MJ however...she's dead meat)