There's literally going to be a book on the subject.
Going to say my favorites are
- Spider-Man and Mary Jane Watson (Spider-Man franchise)
- Max and Chloe (Life is Strange franchise)
Also like Han and Leia from Star Wars (but don't we all), Paris and Torres from Star Trek, and the O'Briens, also from Star Trek. May not be official (unless you believe "Word of God" r.e. the ending), but I was rooting for Rogue in the X-Men: Evolution triangle between herself, Cyclops, and Jean Grey.
Doctor Strange: "You are the right person to replace Logan."
X-23: "I know there are people who disapprove... Guys on the Internet mainly."
(All-New Wolverine #4)
i dont like romantic stuff but i second fry and leela from futurama, the writers got a good dynamic out of it for many years and their moment in the final episode slightly elevated a pretty "meh" season overall